A recent study reveals that people who stop using new GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight much more quickly than those who end traditional lifestyle regimens.
Research printed in a prominent health publication points out that while obese individuals often shed substantial amounts of their total mass while using the jabs, the weight returns at an estimated rate of 0.8 kg per month after stopping.
"Individuals purchasing these treatments should be cognizant of the potential of fast weight regain when the therapy ends," cautioned expert Dr. Susan Jebb.
That rate of recovery means a reversion to original weight in about one and a half years.
Analyzing Therapies
The research, which looked at 37 of trials involving thousands of participants, contrasted the outcomes of these new drugs with other pills.
Researchers point out that individuals who lose weight through diet and exercise generally have a slower weight regain—perhaps 100 grams monthly—after stopping.
Explaining the Fast Regain
Doctors suggest the mode of action of the jabs accounts for the accelerated weight return.
The injections imitate a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone concentrations several times higher than the body's typical production could lead to the system to produce less of its endogenous GLP-1, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a nutrition expert.
"Discontinuation of this hormone supplement leads to appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Issue?
The NHS recommend the jabs for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians say that, considering the high risk of weight regain, the therapy might need to be ongoing.
This opinion is echoed by drug manufacturers, who state that the results "emphasize the long-term nature of excess weight," akin to managing conditions like diabetes.
Patient Experiences
People who have stopped the medication report a intense return of cravings.
"It felt as if a switch that goes on and you become starving," recalled a patient.
The struggle is exacerbated if patients have not adopted permanent lifestyle or habit modifications during treatment.
Growing Use
Recent estimates suggest that millions of people in the UK have used these injections in the past year, with demand remaining high.
- Adoption is higher among females compared to men.
- The middle-aged demographic shows the greatest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
In conclusion, clinicians emphasize that while these medications are powerful agents for shedding pounds, they are not a standalone cure and long-term success likely depends on combined behavioural changes.
